I finally talked to the vet. The mass that was removed from Jesse's foot was cellulitus. This is caused by a previous puncture to the area.
We knew that there were two puncture marks, but could not come to a conclusion until the vet and I talked - a possible snake bite. Which makes complete sense.
Thankfully, Jesse does not have cancer, but is going back to the vet today for removal of his stitches and medication.
From what we've see around here, it could have been a nasty bite from a black water snake. They are very aggressive snakes, and we have them in the creek, and the ditch that drains between the creek and the farm fields. We've even seen them in our septic lines that feed to the cap area.